| Total | 532 | 215 | (40%) | 109 | (20%) | 208 | (39%) |
| Casa | 265 | 153 | (58%) | 50 | (19%) | 62 | (23%) |
| Trasferta | 267 | 62 | (23%) | 59 | (22%) | 146 | (55%) |
P | 2021-12-11 | San José |  | 0-3 |  | Jorge Wilstermann | G30 | ||
S | 2021-12-05 | The Strongest |  | 2-0 | | San José | G29 | ||
S | 2021-11-30 | San José | | 0-2 |  | Oriente Petrolero | G28 | ||
S | 2021-11-26 | Nacional Potosí |  | 7-1 | | San José | G27 | ||
S | 2021-11-22 | San José | | 1-2 |  | Real Santa Cruz | G26 | ||
S | 2021-11-01 | Independiente Petrolero |  | 4-0 | | San José | G25 | ||
S | 2021-10-28 | Real Tomayapo |  | 1-0 | | San José | G24 | ||
S | 2021-10-22 | San José | | 1-4 |  | Aurora | G23 | ||
S | 2021-10-20 | Bolívar |  | 4-1 | | San José | G22 | ||
S | 2021-09-25 | San José | | 1-2 |  | Blooming | G21 | ||
S | 2021-09-21 | Guabirá |  | 4-0 | | San José | G20 | ||
P | 2021-09-17 | San José | | 0-0 |  | Real Potosí | G19 | ||
S | 2021-09-11 | Royal Pari FC |  | 6-1 | | San José | G18 | ||
S | 2021-08-21 | San José | | 0-4 |  | Always Ready | G17 | ||
S | 2021-08-19 | Atlético Palmaflor |  | 1-0 | | San José | G16 | ||
S | 2021-08-15 | Jorge Wilstermann | | 4-0 | | San José | G15 | ||
S | 2021-08-07 | San José | | 0-1 | | The Strongest | G14 | ||
S | 2021-08-05 | Oriente Petrolero | | 4-0 | | San José | G13 | ||
S | 2021-07-30 | San José | | 0-4 | | Nacional Potosí | G12 | ||
S | 2021-07-26 | Real Santa Cruz | | 5-0 | | San José | G11 |
