| Pt. | P | V | P | S | GF | GS | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Colón | 10 | 6 | 3 | 1 | 2 | 8 | 8 |
| 2 |  | Cerro Porteño | 8 | 6 | 2 | 2 | 2 | 5 | 4 |
| 3 |  | Olimpia | 8 | 6 | 2 | 2 | 2 | 4 | 4 |
| 4 |  | Peñarol | 7 | 6 | 2 | 1 | 3 | 5 | 6 |
| 2022/04/06 | GrpG | Colón | | 2-1 | | Peñarol | ||||
| 2022/04/06 | GrpG | Olimpia | | 0-0 | | Cerro Porteño | ||||
| 2022/04/13 | GrpG | Cerro Porteño | | 3-1 | | Colón | ||||
| 2022/04/13 | GrpG | Peñarol | | 2-1 | | Olimpia | ||||
| 2022/04/28 | GrpG | Cerro Porteño | | 1-0 | | Peñarol | ||||
| 2022/04/29 | GrpG | Olimpia | | 0-0 | | Colón | ||||
| 2022/05/05 | GrpG | Colón | | 2-1 | | Cerro Porteño | ||||
| 2022/05/05 | GrpG | Olimpia | | 1-0 | | Peñarol | ||||
| 2022/05/18 | GrpG | Peñarol | | 0-0 | | Cerro Porteño | ||||
| 2022/05/19 | GrpG | Colón | | 2-1 | | Olimpia | ||||
| 2022/05/26 | GrpG | Cerro Porteño | | 0-1 | | Olimpia | ||||
| 2022/05/26 | GrpG | Peñarol | | 2-1 | | Colón |
 | Qualificazione |
|
| 2 |
|
Rafael Navarro Palmeiras | 7 G |
| 2 |
|
Rony Palmeiras | 7 G |
| 2 |
|
Lucas Janson Vélez Sarsfield | 7 G |
| 5 |
|
Julián Álvarez River Plate | 6 G |
| 2 |
|
Enrique Triverio The Strongest | 4 AST |
| 2 |
|
Wesley Palmeiras | 4 AST |
| 2 |
|
Yago Pikachu Fortaleza | 4 AST |
| 5 |
|
Kevin Velasco Deportivo Cali | 3 AST |
