| Pt. | P | V | P | S | GF | GS | DG | Pt.C | PC | VC | PC | SC | GFC | GSC | Pt.T | PT | VT | PT | ST | GFT | GST | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Shakhtar Donetsk | 47 | 18 | 15 | 2 | 1 | 49 | 10 | +39 | 24 | 9 | 8 | 0 | 1 | 29 | 7 | 23 | 9 | 7 | 2 | 0 | 20 | 3 | a | ||
| 2 |  | Dynamo Kyiv | 45 | 18 | 14 | 3 | 1 | 47 | 9 | +38 | 20 | 9 | 6 | 2 | 1 | 22 | 3 | 25 | 9 | 8 | 1 | 0 | 25 | 6 | a | ||
| 3 |  | Dnipro-1 | 40 | 18 | 13 | 1 | 4 | 35 | 17 | +18 | 24 | 9 | 8 | 0 | 1 | 22 | 8 | 16 | 9 | 5 | 1 | 3 | 13 | 9 | a | ||
| 4 |  | Zorya | 36 | 18 | 11 | 3 | 4 | 37 | 19 | +18 | 19 | 9 | 6 | 1 | 2 | 13 | 4 | 17 | 9 | 5 | 2 | 2 | 24 | 15 | a | ||
| 5 |  | Vorskla | 33 | 18 | 9 | 6 | 3 | 30 | 18 | +12 | 21 | 10 | 6 | 3 | 1 | 22 | 8 | 12 | 8 | 3 | 3 | 2 | 8 | 10 | a | ||
| 6 |  | PFC Oleksandriya | 26 | 18 | 7 | 5 | 6 | 19 | 16 | +3 | 12 | 7 | 4 | 0 | 3 | 10 | 6 | 14 | 11 | 3 | 5 | 3 | 9 | 10 | a | ||
| 7 |  | Desna | 25 | 18 | 7 | 4 | 7 | 22 | 27 | -5 | 14 | 9 | 4 | 2 | 3 | 13 | 12 | 11 | 9 | 3 | 2 | 4 | 9 | 15 | a | ||
| 8 |  | Kolos Kovalivka | 24 | 18 | 7 | 3 | 8 | 14 | 23 | -9 | 13 | 10 | 4 | 1 | 5 | 9 | 12 | 11 | 8 | 3 | 2 | 3 | 5 | 11 | a | ||
| 9 |  | FC Veres | 23 | 18 | 6 | 5 | 7 | 15 | 20 | -5 | 16 | 9 | 4 | 4 | 1 | 8 | 5 | 7 | 9 | 2 | 1 | 6 | 7 | 15 | a | ||
| 10 |  | Metalist 1925 Kharkov | 19 | 18 | 6 | 1 | 11 | 17 | 29 | -12 | 12 | 8 | 4 | 0 | 4 | 12 | 14 | 7 | 10 | 2 | 1 | 7 | 5 | 15 | a | ||
| 11 |  | Rukh Vynnyky | 18 | 17 | 4 | 6 | 7 | 16 | 21 | -5 | 13 | 8 | 3 | 4 | 1 | 8 | 6 | 5 | 9 | 1 | 2 | 6 | 8 | 15 | a | ||
| 12 |  | FC Lviv | 17 | 18 | 4 | 5 | 9 | 14 | 30 | -16 | 7 | 10 | 1 | 4 | 5 | 7 | 16 | 10 | 8 | 3 | 1 | 4 | 7 | 14 | a | ||
| 13 |  | Chornomorets | 14 | 18 | 3 | 5 | 10 | 20 | 40 | -20 | 9 | 10 | 2 | 3 | 5 | 11 | 22 | 5 | 8 | 1 | 2 | 5 | 9 | 18 | a | ||
| 14 |  | Inhulets Petrove | 13 | 17 | 3 | 4 | 10 | 13 | 28 | -15 | 8 | 8 | 2 | 2 | 4 | 7 | 11 | 5 | 9 | 1 | 2 | 6 | 6 | 17 | a | ||
| 15 |  | Mynai | 10 | 18 | 1 | 7 | 10 | 12 | 30 | -18 | 8 | 9 | 1 | 5 | 3 | 8 | 12 | 2 | 9 | 0 | 2 | 7 | 4 | 18 | a | ||
| 16 |  | Mariupol | 8 | 18 | 2 | 2 | 14 | 21 | 44 | -23 | 0 | 9 | 0 | 0 | 9 | 9 | 25 | 8 | 9 | 2 | 2 | 5 | 12 | 19 | a |
 | Champions League - Fase a gironi |
| Champions League - 2º turno Preliminare |
| Conference League - Terzo Turno di Qualificazione |
| Conference League - Secondo Turno di Qualificazione |
| Play out |
| Retrocessione |
| Fase | Data | Ora | |||||
|---|---|---|---|---|---|---|---|
| 0 | G27 | FC Lviv | Ann. | Chornomorets | 2022-04-30 | 00:00 | |
| 0 | G27 | Mynai | Ann. | Rukh Vynnyky | 2022-04-30 | 00:00 | |
| 0 | G27 | Mariupol | Ann. | FC Veres | 2022-04-30 | 00:00 | |
| 0 | G27 | PFC Oleksandriya | Ann. | Desna | 2022-04-30 | 00:00 | |
| 0 | G27 | Kolos Kovalivka | Ann. | Zorya | 2022-04-30 | 00:00 | |
| 0 | G27 | Dnipro-1 | Ann. | Dynamo Kyiv | 2022-04-30 | 00:00 | |
| 0 | G27 | Shakhtar Donetsk | Ann. | Vorskla | 2022-04-30 | 00:00 | |
| 0 | G27 | Inhulets Petrove | Ann. | Metalist 1925 Kharkov | 2022-04-30 | 00:00 | |
| 0 | G28 | Dynamo Kyiv | Ann. | Mariupol | 2022-05-07 | 02:00 | |
| 0 | G28 | Mynai | Ann. | Dnipro-1 | 2022-05-07 | 02:00 | |
| 0 | G28 | PFC Oleksandriya | Ann. | Rukh Vynnyky | 2022-05-07 | 02:00 | |
| 0 | G28 | Chornomorets | Ann. | Vorskla | 2022-05-07 | 02:00 | |
| 0 | G28 | FC Lviv | Ann. | Kolos Kovalivka | 2022-05-07 | 02:00 | |
| 0 | G28 | Desna | Ann. | Shakhtar Donetsk | 2022-05-07 | 02:00 | |
| 0 | G28 | Zorya | Ann. | Metalist 1925 Kharkov | 2022-05-07 | 02:00 | |
| 0 | G28 | FC Veres | Ann. | Inhulets Petrove | 2022-05-07 | 02:00 |
