| 21-04 | 14:00 | Getafe | 3-0 | Sevilla | G33 | FG | |||
| 21-04 | 16:15 | Real Madrid | 3-0 | Athletic | G33 | FG | |||
| 21-04 | 18:30 | Villarreal | 2-1 | Leganés | G33 | FG | |||
| 21-04 | 20:45 | Real Betis | 1-2 | Valencia | G33 | FG |
| 21-04 | 14:30 | Everton | 4-0 | Manchester United | G35 | FG | |||
| 21-04 | 17:00 | Arsenal | 2-3 | Crystal Palace | G35 | FG | |||
| 21-04 | 17:00 | Cardiff City | 0-2 | Liverpool | G35 | FG | |||
| 22-04 | 21:00 | Chelsea | vs | Burnley | G35 | 1.27 | 6.40 | 13.00 | sd |
| 21-04 | 15:30 | SC Freiburg | 0-4 | Borussia Dortmund | G30 | FG | |||
| 21-04 | 18:00 | Hertha BSC | 0-0 | Hannover 96 | G30 | FG | |||
| 22-04 | 20:30 | Wolfsburg | vs | Eintracht Frankfurt | G30 | 2.84 | 3.68 | 2.50 | sd |
| 21-04 | 15:00 | Toulouse | 0-0 | Lille | G33 | FG | |||
| 21-04 | 15:00 | Nantes | 3-2 | Amiens | G33 | FG | |||
| 21-04 | 17:00 | Stade de Reims | 0-2 | Saint-Étienne | G33 | FG | |||
| 21-04 | 21:00 | Paris SG | 3-1 | Monaco | G33 | FG |
| 22-04 | 19:00 | Napoli | vs | Atalanta | G33 | 2.04 | 3.68 | 3.84 | sd |
| 22-04 | 15:00 | vs | GrpB | 1.49 | 5.00 | 5.60 | sd | ||
| 22-04 | 17:20 | vs | GrpB | sd | |||||
| 22-04 | 17:30 | vs | GrpD | 2.92 | 3.20 | 2.45 | sd | ||
| 22-04 | 18:00 | vs | GrpD | 1.69 | 3.80 | 4.62 | sd |
| 21-04 | 17:00 | 2-1 | MF | FG | |||||
| 21-04 | 18:00 | 0-1 | MF | FG |
| 22-04 | 15:00 | Hellas Verona | vs | Benevento | G34 | 2.51 | 3.12 | 3.04 | sd |
| 22-04 | 18:00 | Brescia | vs | Salernitana | G34 | 1.50 | 4.20 | 7.00 | sd |
| 22-04 | 21:00 | Cittadella | vs | Cremonese | G34 | 1.89 | 3.26 | 4.72 | sd |
| 22-04 | 21:00 | Perugia | vs | Lecce | G34 | 2.51 | 3.24 | 2.94 | sd |
| 22-04 | 21:00 | Foggia | vs | Livorno | G34 | 2.00 | 3.24 | 4.20 | sd |
| 22-04 | 21:00 | Carpi | vs | Pescara | G34 | 3.07 | 3.18 | 2.46 | sd |
| 22-04 | 21:00 | Palermo | vs | Padova | G34 | 1.44 | 4.04 | 8.80 | sd |
| 22-04 | 21:00 | Ascoli | vs | Venezia | G34 | 2.16 | 3.05 | 3.92 | sd |
| 22-04 | 21:00 | Cosenza | vs | Spezia | G34 | 2.52 | 2.86 | 3.32 | sd |
| 22-04 | 21:15 | Benfica | vs | Marítimo | G30 | 1.11 | 9.60 | 22.00 | sd |
| 21-04 | 15:30 | FK Ural | 2-1 | Rubin Kazan | G24 | FG | |||
| 21-04 | 18:00 | Spartak Moskva | 2-0 | FC Yenisey | G24 | FG |
| 21-04 | 14:30 | Fortuna Sittard | 2-1 | NAC Breda | G31 | FG | |||
| 21-04 | 16:45 | PSV | 3-1 | ADO Den Haag | G31 | FG |
| 21-04 | 22:05 | DC United | 0-2 | New York City FC | GrpA | FG |
| 22-04 | Astra Giurgiu | vs | CFR Cluj | MF | sd |
| 21-04 | 18:00 | Panionios | 2-1 | PAS Giannina | G29 | FG | |||
| 21-04 | 18:00 | Xanthi | 2-0 | Apollon Smyrnis | G29 | FG | |||
| 21-04 | 18:00 | AEK | 0-1 | Larissa | G29 | FG | |||
| 21-04 | 18:00 | Atromitos | 2-0 | Panathinaikos | G29 | FG | |||
| 21-04 | 18:00 | Lamia | 1-3 | Olympiacos | G29 | FG | |||
| 21-04 | 18:00 | PAOK | 5-0 | Levadiakos FC | G29 | FG | |||
| 21-04 | 18:00 | OFI | 1-1 | Asteras Tripolis | G29 | FG | |||
| 21-04 | 18:00 | Panetolikos | 1-2 | Aris | G29 | FG |
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